Now the molybdenum in the meals that we often eat is readily absorbed. But the sulfuric acid can form sulfate molybdenum which can affect the absorption of molybdenum. At the same time, sulfate can also inhibit the renal tubular reabsorption to molybdenum, and the excretion from the kidney will be increased. Therefore, the increasing of sulfur amino acid in body can promote the excretion of urine molybdenum. The main excretion of molybdenum is from the urine, a small part is discharged with bile. The molybdenum sheet lacks of dominantly inherited molybdenum deficiency metabolic defect, there are still reports of the occurrence of total potential nutrition.
If the content of molybdenum is excessive, human and animal organism have strong internal stability mechanism to molybdenum, so the molybdenum compounds intake by mouth are not easy to cause poisoning. According to the report, live in the Armenia area residents daily molybdenum intake up to 10~15mg; the local gout disease with particularly high incidence is linked to this. Molybdenum smelter workers may also have excessive intake of molybdenum because of the inhalation of dust containing molybdenum. According to the survey, the serum levels of molybdenum, molybdenum slice xanthine oxidase activity, blood and urine uric acid levels of these workers are all significantly higher than the general population. The metabolism can absorb the molybdenum compounds in meals and drinking water. About 88%-93% of soluble ammonium molybdate englobed by mouth can be absorbed. The absorption to molybdenum of all kinds of sulfur compounds in diet have a strong inhibitory effect, and molybdenum sulfide can only absorb about 5% molybdenum after the oral administration. Molybdate absorbed can still connect with macroglobulin in blood in a form of molybdic acid, and have a loose binding with red blood cell. Most of molybdenum in the blood is absorbed by the liver, kidney.
Part of molybdate in the liver is transformed into molybdenum containing enzymes, and the left parts are formed into cofactor containing molybdenum combined with the petering which is stored in the liver. The body mainly in the form of molybdate excreted molybdenum by renal. When the dietary molybdenum intake increased, the renal excretion of molybdenum is increasing. Therefore, the human body is mainly excreted through the kidneys rather than through the control absorption to keep the body balanced of molybdenum. In addition, there is also a certain amount of molybdenum with bile excretion.
Catalytic hypoxanthine xanthine oxidase converted to xanthine, and then transformed into uric acid. Oxidation and detoxification of aldehyde oxidase catalytic pyrimidine, purine, pteridines and related compounds. Sulfite oxidase catalyzed sulfite to sulfate conversion. Researchers also found that molybdate can protect the glucocorticoid receptor and keep it have activity.